World Neurosurg
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A standard post-concomitant radiochemotherapy involving adjuvant temozolomide (TMZ) was stopped after 6 cycles for high-grade gliomas (HGG). Several studies demonstrated that prolonged TMZ treatment increased survival for these patients. ⋯ During adjuvant TMZ treatment, tumor volume decreased significantly (P = 0.042, and P = 0.005, respectively) in patients with GBM and AA. Prolonged TMZ administration improved OS, without increased toxicity.
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We previously reported a favorable outcome in a case series of patients with oligodendrogliomas treated with upfront chemotherapy; however, their progression-free survival (PFS) was relatively short considering their long-term overall survival (OS). This suggests that salvage treatments after progression were effective. However, the clinical impact of salvage treatments on outcomes of patients with recurrent oligodendrogliomas has not been precisely investigated. ⋯ In isocitrate dehydrogenase-mutant and 1p/19q-codeleted oligodendrogliomas, most of the tumors that demonstrated early progression appeared as local, nonlethal lesions, which have been well-controlled by salvage treatments. A precise diagnosis of oligodendrogliomas using molecular parameters is crucial to receive the best benefit from salvage treatment.
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Comparative Study
Comparison of Clinical and Radiologic Outcome of Three-Dimensional Correction in Lenke 5C Curve: Uniplanar Versus Polyaxial Pedicle Screws.
To evaluate radiologic and clinical outcome of three-dimensional correction using the uniplanar pedicle screw (UPS) combined with vertebral body derotation technique for treatment of Lenke 5C adolescent idiopathic scoliosis. ⋯ The application of UPS combined with vertebral body derotation technique can reduce vertebral rotation and obtain better patient self-image score when favorable coronal and sagittal realignment is achieved. This improvement remains superior during 2-year follow-up. This combined application is a promising option to achieve spinal three-dimensional correction in treating Lenke 5C curve.
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Case Reports
Ethmoid Meningoencephalocele in a Patient with Cerebrofacial Arteriovenous Metameric Syndrome.
Skull base meningoencephaloceles are a rare condition, frequently secondary to traumatic or iatrogenic causes. Cerebrofacial arteriovenous metameric syndrome (CAMS) is characterized by the presence of retinal, facial, and cerebral arteriovenous malformations (AVMs) with metameric distribution. To our knowledge, this is the first reported case associating these 2 conditions. ⋯ We report the unusual association between the development of a meningoencephalocele and a metameric syndrome, and comment on clinical implications in the management of this patient.
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Case Reports
Cardioversion-Responsive Ventriculoatrial Shunt Malfunction Precipitated by Atrial Fibrillation.
Ventriculoatrial shunts are common alternatives for patients who cannot tolerate ventriculoperitoneal shunts. The majority of ventriculoatrial shunt malfunctions are related to mechanical problems. We report an interesting case of ventriculoatrial shunt malfunction due to elevated central venous pressure from new-onset atrial fibrillation. ⋯ The cause of this patient's VA shunt malfunction was likely associated with his new onset atrial fibrillation.