World Neurosurg
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Review Meta Analysis
Therapeutic Targeting of the Notch Pathway in Glioblastoma.
Glioblastoma (GBM) is the most common and deadly form of brain tumor. After standard treatment of resection, radiotherapy, and chemotherapy, the 5-year survival is <5%. In recent years, research has uncovered several potential targets within the Notch signaling pathway, which may lead to improved patient outcomes. ⋯ Recent literature suggests targeting the Notch pathway has great potential for future therapies for GBM.