World Neurosurg
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Spinal surgery is a procedure that causes intense and severe pain in the postoperative period. Erector spinae plane (ESP) block can target the dorsal-ventral rami of thoracolumbar nerves, but its effect on lumbar surgery is unclear. The aim of this study was to investigate the effect of the ESP block on postoperative opioid consumption and pain scores in patients undergoing spinal surgery. ⋯ ESP block can be used in multimodal analgesia practice to reduce opioid consumption and relieve acute postoperative pain in patients undergoing open lumbar decompression surgery.
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Review Meta Analysis
MicroRNA Expression Profiles, Target Genes and Pathways in Intervertebral Disc Degeneration; A Meta-analysis of Three Microarray Studies.
Determining the expression profile and target genes of microRNA (miRNA) would assist in determining the pathophysiologic pathways in intervertebral disk degeneration (IDD). The aim of this study was to determine the expression profile of miRNA in degenerated intervertebral disks compared with normal healthy intervertebral disks. ⋯ We found that the identified miRNAs through meta-analysis are candidate predictive markers for IDDs through different pathways.