World Neurosurg
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Microscopic delineation and clearance of tumor cells at neurosurgical excision margins potentially reduce tumor recurrence and increase patient survival. Probe-based in vivo fluorescence microscopy technologies are promising for neurosurgical in vivo microscopy. ⋯ We demonstrate the utility of a 3D-printed, flexible probe microscope for high-resolution microscopic imaging with increased architectural detail. Enhanced in vivo imaging using this device may improve our ability to detect and decrease microscopic tumor burden at excision margins during neurosurgical procedures.
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Review Meta Analysis
The efficacy and safety of epsilon-aminocaproic acid for blood loss and transfusions in spinal deformity surgery: A meta-analysis.
To assess the efficacy and safety of epsilon-aminocaproic acid (EACA) in reducing the blood loss and transfusion volume during open spinal deformity surgery. ⋯ This meta-analysis demonstrated that EACA could be safe and potentially efficacious for reducing blood loss and transfusions volume in patients with spinal deformity surgeries when compared with placebo. In light of the significant heterogeneity, the findings of this meta-analysis should be confirmed in methodologically rigorous and adequately powered clinical trials.
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Meta Analysis Comparative Study
Incidence and outcomes of C5 palsy and axial pain after open-door laminoplasty or laminectomy and fusion: a meta-analysis.
C5 palsy and axial pain are significant factors affecting the quality of life after posterior cervical surgery; however, there has been no clear and supportive conclusion on which method is more suitable in a certain case. As a result, we compare the clinical outcomes, complication rates, and anatomical changes between open-door laminoplasty (ODL) and laminectomy and fusion (LF) for cervical spondylotic myelopathy. This is a systematic literature review and meta-analysis. ⋯ Our results demonstrate that the lower incidence of C5 palsy and axial pain can be achieved by using ODL compared with LF. However, current data only provide weak support, if any, favoring ODL over for clinical improvement in reduce these 2 complications.
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The optimal treatment of brain metastases recurring after radiosurgery (BMRS) remains an area of active investigation. Stereotactic laser ablation (SLA, also known as laser interstitial thermal therapy) has recently emerged as a potential treatment option. ⋯ Our analysis provides support for continued development of SLA as a treatment of BMRS. Standardization of periprocedural management will be needed.
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Comparative Study
Predicting outcomes for cerebral aneurysms treated with flow diversion: A comparison between four grading scales.
Despite the development of 4 grading scales of angiographic outcome after flow diversion for cerebral aneurysms, none have been widely adopted in the neurosurgical literature, nor have any been validated in an independent dataset. We evaluated the reported grading scales for their ability to predict aneurysm occlusion at follow-up. ⋯ Although the FDSS was the only reported grading scale that was significantly associated with occlusion at follow-up, its ability to predict occlusion fell below the typical level for widespread clinical utility. The high rate of eventual occlusion of most aneurysms after flow diversion likely limits the clinical utility of a grading score for this application.