World Neurosurg
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Trigeminal neuralgia (TN) is a common cranial nerve disease. Meanwhile, it is suggested in some studies that orofacial pain can also lead to some psychological diseases. Therefore, the current study was carried out aiming to explore the relationship between depression as well as anxiety and TN; at the same time, the effect on the postoperative outcome of microvascular decompression (MVD) would also be explored. ⋯ The findings of this study reveal that depression and anxiety are closely associated with the incidence of TN, which may also affect the outcome of patients undergoing MVD.
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Concomitant atherosclerotic stenoses are commonly encountered in emergent large vessel occlusion. This study attempted to prove whether or not the pattern of atherosclerotic stenosis other than symptomatic occlusion is associated with pretreatment collateral status among patients with emergent large vessel occlusion. ⋯ Concomitant intracranial atherosclerotic stenosis other than symptomatic occlusion might be a crucial factor associated with pretreatment collateral status among patients with emergent large vessel occlusion.
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Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ. ⋯ Our findings suggest that TQ would be a potential therapeutic agent in addition to GK to enhance the antitumor effect of irradiation. Further studies are required to support our findings.