World Neurosurg
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Cervical disk protrusion is a common pathology. Anterior diskectomy and fusion is considered the gold standard of treatment, although anterior arthroplasty has gained some acceptance in the past decade as an alternative. Posterior cervical minimally invasive diskectomy is a rarely used technique, and there is less literature discussing this procedure. ⋯ A 5-mm smooth diamond drill is used to perform a foraminotomy. To avoid nerve root or spinal cord manipulation, it is often necessary to remove some of the rostral aspect of the inferior pedicle to gain access to the axilla and disk protrusion. The procedure is rapid, well tolerated, and performed as outpatient, and it results in a rapid return to normal activity.
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We sought to investigate the long-term outcome of pulmonary function for arthrogryposis multiplex congenita (AMC) patients undergoing posterior spinal fusion (PSF) and to further determine influential factors. ⋯ The pulmonary function of AMC patients can be well improved through PSF surgery. It was remarkably associated with the correction of curve magnitude and restoration of thoracic kyphosis.
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Observational Study
Are Two-Dimensional Morphometric Measures Reflective of Disease Severity in Adult Chiari I Malformation?
Two-dimensional (2D) morphometric measures have been previously used to diagnose Chiari I malformation (CMI) and distinguish patients from healthy subjects. There is, however, a paucity of literature regarding whether morphometric differences exist across the range of CMI disease severity. We evaluated whether 2D morphometrics demonstrate significant changes across standardized grades of CMI severity in adults. ⋯ Our study indicated that 2D morphometrics are not reflective of CMI disease severity as indicated by the CSI grading system. The findings of our study support the need for further investigation into whether non-2D morphometric variables can be used as markers of disease severity.
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Observational Study
Early neutrophil to lymphocyte ratio is a prognostic marker in acute ischemic stroke after successful revascularization.
To explore the association between early neutrophil-to-lymphocyte ratio (ENLR) and prognosis of anterior circulation large-vessel occlusion stroke (LVOS) after patients undergo endovascular treatment (EVT) with successful revascularization. ⋯ Increased ENLR after successful revascularization is independently associated with poor prognosis. These findings suggest that ENLR could be used to inform treatment strategies for patients who experience anterior circulation LVOS.
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Gliomas are the most common type of central nervous system tumor in adults, and they have an extremely poor prognosis. Gliomas are classified into 4 grades, with low-grade gliomas (LGGs) constituting grades I and II and glioblastoma multiforme (GBM) constituting grade IV. Breast cancer susceptibility genes BRCA1 and BRCA2 play a role in DNA repair and are required for genome stability. ⋯ Our findings suggest that BRCA1 and BRCA2 can be regarded as poor prognostic factors in patients with glioma, with greater significance in patients with LGG. In the future, more in-depth experiments will enable us to elucidate the mechanism of gliomagenesis and identify potential gene therapy targets.