J Orofac Pain
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To establish a quantitative sensory testing (QST) profile in the trigeminal (V) area and test for site and gender differences in healthy humans. ⋯ Application of this standardized QST protocol may allow for a better understanding of the underlying mechanisms from somatosensory phenotypes and provide basic information for the study of sensory dysfunctions in the V area.
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To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory hyperalgesia, and to use this model to investigate the antinociceptive effects of clomipramine and tramadol, two drugs used for the treatment of neuropathic pain. ⋯ Nociceptive responses in this neuropathic pain model in mice exhibited a pattern consistent with the pain described by posttraumatic trigeminal neuropathic patients. The selective antihyperalgesic effect obtained with two commonly used drugs for treating neuropathic pain confirms the validity of this preclinical model.
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Review Meta Analysis
Effectiveness of low-level laser therapy in temporomandibular disorders: a systematic review and meta-analysis.
To assess the scientific evidence on the efficacy of low-level laser therapy (LLLT) in the treatment of temporomandibular disorders (TMD). ⋯ Currently, there is no evidence to support the effectiveness of LLLT in the treatment of TMD.
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Randomized Controlled Trial Comparative Study
Conditioned pain modulation evoked by different intensities of mechanical stimuli applied to the craniofacial region in healthy men and women.
To investigate systematically whether conditioned pain modulation (CPM) evoked by tonic mechanical stimuli applied to the craniofacial region is intensity-, assessment site-, and gender-dependent. ⋯ CPM evoked by mechanical stimulation of the craniofacial region is intensity-dependent but not assessment site- or gender-dependent.
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Controlled Clinical Trial
A mandibular advancement appliance reduces pain and rhythmic masticatory muscle activity in patients with morning headache.
To evaluate the influence of an oral appliance on morning headache and orofacial pain in subjects without reported sleep-disordered breathing (SDB). ⋯ Short-term use of an MAA is associated with a significant reduction in morning headache and orofacial pain intensity. Part of this reduction may be linked to the concomitant reduction in RMMA.