J Orofac Pain
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To investigate whether trigeminal manifestations of pain, sensitization, and vasomotor responses following the intradermal injection of capsaicin to the foreheads differ from manifestations following injection of capsaicin in the forearms of healthy humans. Dose dependency and sex-related differences of the evoked responses were also studied. ⋯ Capsaicin-evoked sensory and vasomotor manifestations were different in the forehead and forearm. The differences are most likely due to the differences in innervation density and neurovascular activity. The capsaicin-induced effects were demonstrated to be dose-dependent and sex-related phenomena.
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(1) To use psychometrically sound measures to characterize the pain levels and pain-related interference associated with recurrent aphthous ulcers (RAU); (2) to determine whether subjects with RAU report clinically significant psychologic symptoms; and (3) to examine the relationships between physical characteristics and self-reported psychologic symptoms, pain, and pain-related interference. ⋯ RAU is a moderately painful condition causing some impairment in functioning. Self-reported pain intensity of a sore does not appear to be influenced by psychologic characteristics. However, pain-related interference appears to be related to psychologic and not physical characteristics.
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To document the frequency of self-care in a clinical sample of patients with myofascial temporomandibular disorder (TMD) pain; report the perceived relief and control of pain for each of the self-care behaviors; and to test for associations between the frequency and efficacy of each self-care behavior and pain, depression and sleep quality, as assessed during a clinical visit, and to determine whether the frequency was associated with changes in pain intensity, depression, and sleep quality 30 days later. ⋯ Since people with chronic myofascial TMD pain engage in a range of pain self-care strategies, clinicians need to discuss self-care with patients regularly.
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Randomized Controlled Trial
Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
To test the hypothesis that local injection of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine would significantly attenuate glutamate-evoked masseter mechanical sensitization and muscle pain in healthy young women either taking oral contraceptives (W+OC) or not taking oral contraceptives (W-OC). ⋯ Peripherally administered ketamine had no effect on glutamate-evoked masseter muscle pain and sensitization in healthy young women, which contrasts with recent observations in healthy young men. Further studies will be needed to reveal the mechanisms that underlie this apparent sex-related difference in ketamine-mediated analgesia.
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This topical review presents an overview of orofacial manifestations associated with the more common connective tissue diseases affecting multiple organs. The orofacial manifestations associated with these autoimmune disorders include oral mucosa alterations, salivary gland pathosis, sensory neuropathies, headaches, and temporomandibular disorders. ⋯ An understanding of the orofacial manifestations associated with these systemic diseases will enable the pain practitioner to establish an appropriate diagnosis within the context of the underlying systemic disease. This will allow the practitioner the opportunity to contribute and collaborate as a member of a multidisciplinary health-care team in the management of these systemic autoimmune diseases.