Kardiologiya
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Randomized Controlled Trial Comparative Study
[Indirect comparison of changes of parameters of hemostasis during short-term use of ticlopidine and clopidogrel in patients with non-ST elevation acute coronary syndrome].
Effects of thienopyridines ticlopidine (TIC) and clopidogrel (CL) on hemostasis in patients (pts) with non-ST-elevation acute coronary syndromes (NSTEACS) have not been compared. ⋯ In pts with NSTEACS both thienopyridines attenuated acute phase elevation of vWF. The use of TIC in UFH treated pts was associated with indirect signs of decreased thrombin activity and some inhibition of fibrinolysis while the use of CL in enoxaparin treated pts was associated with signs of activation of fibrinolysis.
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Phenomenon of ischemic post-conditioning of the myocardium (attenuation of myocardial damage during reperfusion resulting from interruption of early reperfusion period by repetitive short episodes of ischemia) was discovered in 2003. This paper contains presentation of protective effects of ischemic post-conditioning during ischemia-reperfusion of the myocardium, data on antiarrhythmic effects of post-conditioning in relation to persistent tachyarrhythmias during reperfusion, analysis of possible mechanisms of infarct-limiting effect of post-conditioning, and perspectives of its clinical application.
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Review Comparative Study
[Stroke and other thromboembolic complications of atrial fibrillation. Part VII. Prevention of cardioversion related thromboembolism].
In part VII of a series of papers on epidemiology and drug prevention of stroke and other thromboembolic complications of atrial fibrillation the authors analyze data on frequency and contemporary approaches to prevention of thromboembolic complications related to cardioversion. The stress is made on importance of prescription of indirect anticoagulants to all patients with duration of atrial fibrillation exceeding 48 hours. International normalized ratio should be controlled during anticoagulant therapy and be kept between 2.0 and 3.0 at least for 3-4 weeks before and after restoration of sinus rhythm. Absence of atrial thrombi at transesophageal echocardiography does not exclude possibility of thromboembolic complications of cardioversion conducted without anticoagulant therapy.