Rev Esp Cardiol
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Little information is available on the clinical profile and prognosis of patients with endocarditis and periannular pseudoaneurysms because the presence of pseudoaneurysm itself is considered an indication albeit not an evidence-based indication, for surgery. ⋯ We conclude that the presence of a pseudoaneurysm identifies a subset of endocarditis patients with a high mortality. Pseudoaneurysms are usually located in an aortic position and around prosthetic material. Medical treatment without surgery should be considered when no other surgical indications exist. Lastly the size of a pseudoaneurysm in medically treated patients does not increase over time
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Practice Guideline Guideline
[Clinical guidelines of the Spanish Society of Cardiology in congenital cardiopathy of the newborn].
The use of diagnostic and therapeutic techniques is very important to ensure optimum, effective treatment in patients with heart disease to thereby obtain an adequate cost-benefit relationship. The aim of establishing guidelines for the evaluation and management is to achieve this relationship, but these guidelines are difficult to establish in pediatric cardiology despite 50 years of experience in this field. The physiopathologic peculiarities of newborns, in addition to the complex anatomical features of many heart diseases and their clinical presentation, diagnostic and therapeutic difficulties and the presence of residue, sequela and complications of the surgical technique make the elaboration of such guidelines at this age complex. Guidelines for some heart diseases are presented together with a descriptive analysis and a therapeutic schedule of other congenital heart diseases.
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In the past decades it has become apparent that inflammation plays a role in atherogenesis and rapid coronary artery disease progression. Active, or vulnerable, atheromatous plaques are responsible for acute coronary events and contain high concentrations of inflammatory cells as well as molecules involved in the inflammatory process, such as cytokines, adhesion molecules and growth factors. From a clinical perspective, early detection of these plaques may prevent the occurrence of serious coronary events. ⋯ These results, however, await confirmation by other large, currently ongoing, studies. The infectious hypothesis of atherosclerosis is still a matter of debate; however, this theory has contributed to the rapid advance of our knowledge regarding the pathogenesis of coronary artery disease in the past few years. Moreover, the notion that coronary artery disease can be considered to be an inflammatory condition in its own right has opened new and challenging avenues for research.