The Journal of pediatrics
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The Journal of pediatrics · Feb 2014
Randomized Controlled Trial Comparative StudyFeeding dysfunction in children with single ventricle following staged palliation.
To determine the prevalence of feeding dysfunction in children with single ventricle defects and identify associated risk factors. ⋯ Feeding dysfunction is common in children with single ventricle defects, occurring in 50% of our cohort. Feeding dysfunction is associated with worse growth measures. Current gastrostomy tube use and a single parent household were identified as independent risk factors for feeding dysfunction.
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The Journal of pediatrics · Feb 2014
Randomized Controlled Trial Comparative StudyEarly-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort.
To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. ⋯ We found distinct early-life risk factor profiles for each wheeze phenotype. These findings provide insight into possible wheeze mechanisms and have implications for identifying preventive strategies and addressing clinical management of early-life wheeze.
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The Journal of pediatrics · Feb 2014
Comparative StudyVolumetric capnography in infants with bronchopulmonary dysplasia.
To assess the feasibility of using volumetric capnography in spontaneously breathing small infants and its ability to discriminate between infants with and without bronchopulmonary dysplasia (BPD). ⋯ Volumetric capnography may provide valuable information regarding functional lung alterations related to BPD and might be considered as an alternative to more involved lung function techniques for monitoring chronic lung disease during early infancy.
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The Journal of pediatrics · Feb 2014
Randomized Controlled Trial Multicenter Study Comparative StudyA phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates.
To investigate the safety, efficacy, and pharmacokinetic profile of dexmedetomidine in preterm and full-term neonates ≥ 28 to ≤ 44 weeks gestational age. ⋯ Dexmedetomidine is effective for sedating preterm and full-term neonates and is well-tolerated without significant AEs. Preterm neonates had decreased plasma clearance and longer elimination half-life.
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The Journal of pediatrics · Feb 2014
Multicenter Study Comparative StudyHypothermia and early neonatal mortality in preterm infants.
To evaluate intervention practices associated with hypothermia at both 5 minutes after birth and at neonatal intensive care unit (NICU) admission and to determine whether hypothermia at NICU admission is associated with early neonatal death in preterm infants. ⋯ Simple interventions, such as maintaining DR temperature >25 °C, reducing maternal hypothermia prior to delivery, providing plastic bags/wraps and caps for the newly born infants, and using warm resuscitation gases, may decrease hypothermia at NICU admission and improve early neonatal survival.