The Journal of pediatrics
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The Journal of pediatrics · Mar 2014
Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy.
To evaluate serum neuronal and inflammatory biomarkers to determine whether measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic encephalopathy (HIE), whether serial measurements differ with hypothermia-rewarming, and whether biomarkers correlate with neurological outcomes. ⋯ The severity of the hypoxic-ischemic injury can be stratified at birth because elevated neuronal biomarkers in cord serum correlated with severity of HIE and outcomes.
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The Journal of pediatrics · Mar 2014
Early cerebral oxygen extraction and the risk of death or sonographic brain injury in very preterm infants.
To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. ⋯ Elevated cFTOE values are associated with increased risk of early poor outcome in very preterm infants. Its predictive value is further improved with the addition of GA.
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The Journal of pediatrics · Mar 2014
Early microvascular changes with loss of the glycocalyx in children with type 1 diabetes.
To evaluate the microcirculation of children with type 1 diabetes mellitus who demonstrate no clinical signs of diabetic microangiopathy for the presence of microvascular alterations and glycocalyx perturbation. ⋯ Microvascular alterations, including changes in microvessel distribution and loss of the glycocalyx, can be detected in children with type 1 diabetes mellitus before clinically apparent vascular complications. Our results disclose the glycocalyx as a possible monitoring measurement for earlier detection of diabetic microangiopathy and may provide a basis for new therapeutic strategies aiming at protection or restoration of the glycocalyx.
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The Journal of pediatrics · Mar 2014
Implementation of lipid screening guidelines in children by primary pediatric providers.
To assess the awareness and implementation of lipid guidelines among primary pediatric providers. ⋯ These findings underscore the need to further educate providers and supply easily accessible information on the screening and treatment of childhood lipid disorders.
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The Journal of pediatrics · Mar 2014
Pretransplant serum albumin is an independent predictor of graft failure in pediatric renal transplant recipients.
To determine the prevalence of hypoalbuminemia in children listed for renal transplantation and to evaluate the effect of pretransplant hypoalbuminemia on posttransplant outcomes. ⋯ Considerable regional variation exists in the US with respect to transplantation in children with hypoalbuminemia. Severe hypoalbuminemia is an independent risk factor for graft failure. Transplant centers as well as patients need to be aware of this risk and make informed decisions regarding the optimal timing of transplantation. Whether graft failure is a consequence of the low serum albumin or the reflection of a higher inflammatory milieu remains to be explored.