The Journal of pediatrics
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The Journal of pediatrics · Dec 2012
Clinical TrialTissue Doppler imaging predicts adverse outcome in children with idiopathic pulmonary arterial hypertension.
To evaluate the clinical utility of tissue Doppler imaging (TDI) in assessment of disease severity and prognostic value in children with idiopathic pulmonary arterial hypertension (PAH). ⋯ Tricuspid Em velocity correlated with NYHA functional class as disease severity and may serve as a useful prognostic marker in children with idiopathic PAH. The present study is the initial report to evaluate TDI velocities against midterm outcome variables in a relatively large pediatric PAH population.
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The Journal of pediatrics · Dec 2012
Randomized Controlled TrialLow oxygen saturation target range is associated with increased incidence of intermittent hypoxemia.
To test the hypothesis that preterm infants randomized to a low vs high O(2) saturation target range have a higher incidence of intermittent hypoxemia. ⋯ A low O(2) saturation target was associated with an increased rate of intermittent hypoxemia events that was dependent on postnatal age. The duration and severity of events was comparable between target groups. Further investigation is needed to assess the role of intermittent hypoxemia and their timing on neonatal morbidity.
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The Journal of pediatrics · Nov 2012
Randomized Controlled TrialRandomized crossover study of neurally adjusted ventilatory assist in preterm infants.
To determine whether neurally adjusted ventilatory assist (NAVA), a new method of mechanical ventilation that delivers pressure assistance that is proportional to the electrical activity of the diaphragm (EAdi), could lower the inspiratory pressure and respiratory muscle load in preterm infants supported with ventilators. ⋯ NAVA lowered PIP and reduced respiratory muscle load in preterm infants at equivalent inspiratory oxygen fraction and partial pressure of CO(2) of capillary blood in comparison with SIMV with PS.