The Journal of pediatrics
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The Journal of pediatrics · Nov 2012
Intramuscular dexmedetomidine: an effective route of sedation preserves background activity for pediatric electroencephalograms.
To describe the efficacy and outcome of dexmedetomidine (Dex) via the intramuscular (IM) route for sedation for electroencephalography (EEG). ⋯ We describe Stage 3 sleep and preserved background activity in response to Dex. We present the IM route as a new method, which preserves background EEG activity to provide safe and effective sedation for EEG studies.
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The Journal of pediatrics · Oct 2012
Randomized Controlled TrialThe two-thumb technique using an elevated surface is preferable for teaching infant cardiopulmonary resuscitation.
To determine whether the two-thumb technique is superior to the two-finger technique for administering chest compressions using the floor surface and the preferred location for performing infant cardiopulmonary resuscitation (CPR) (ie, floor, table, or radiant warmer). ⋯ The two-thumb technique is superior to the two-finger technique, achieving greater depth, less variability, and less decay over time. The table was considered most comfortable and less tiring. The two-thumb technique should be the preferred method for teaching lay persons infant CPR preferably using an elevated firm surface.
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The Journal of pediatrics · Oct 2012
The EPICure study: association between hemodynamics and lung function at 11 years after extremely preterm birth.
To investigate the relationship between disturbed lung function and large-artery hemodynamics in school-age children born extremely preterm (EP) (at 25 completed weeks of gestation or less). ⋯ The independent association between impaired lung function and cardiovascular physiology in early adolescence implies higher cardiovascular risk for children born EP, and suggests that prevention of chronic neonatal lung disease may be a priority in reducing later cardiovascular risk in preterm infants.
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The Journal of pediatrics · Oct 2012
Risk factors for mortality in children with abusive head trauma.
We sought to identify risk factors for mortality in a large clinical cohort of children with abusive head trauma. ⋯ Low initial GCS score, RH, intraparenchymal hemorrhage, and cerebral edema are independently associated with mortality in abusive head trauma. Knowledge of these risk factors may enable researchers and clinicians to improve the care of these vulnerable children.
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The Journal of pediatrics · Oct 2012
Pulmonary innate immunity in children with protracted bacterial bronchitis.
To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human β-defensin-2 [hBD2], mannose-binding lectin [MBL], and surfactant protein-A [SP-A]), the relationship with airway neutrophilia and infection, and cytokine production of stimulated BAL cells in children with current protracted bacterial bronchitis (PBB), children with resolved PBB (PBB well), and controls. ⋯ In children's airways, hBD2, but not MBL and SP-A, relates to inflammation and infection. In children with PBB, mechanisms involving airway hBD2 and MBL are augmented. These pulmonary innate immunity components and the ability of BAL cells to respond to stimuli are unlikely to be deficient.