The Journal of pediatrics
-
The Journal of pediatrics · Jun 1997
Comparative StudyCardiac troponin I in pediatrics: normal values and potential use in the assessment of cardiac injury.
To establish normal values and determine the impact of congenital or acquired heart disease on serum cardiac troponin I (cTnI). ⋯ Cardiac troponin-I values are generally not elevated in children with stable cardiac disease or general pediatric conditions. In the context of severe acute illness, significant elevation of cTnI may be an indicator of poor outcome. Elevation of cTnI may also have diagnostic value in cases when cardiac contusion is suspected.
-
The Journal of pediatrics · May 1997
Randomized Controlled Trial Comparative Study Clinical TrialComparison of skin stapling devices and standard sutures for pediatric scalp lacerations: a randomized study of cost and time benefits.
To compare the total costs and the physician time requirements for suture and staple repair of pediatric scalp lacerations. ⋯ Stapling is faster and less expensive than suturing in the repair of uncomplicated pediatric scalp lacerations, with no additional complications. Physicians who treat children with scalp lacerations should consider the use of stapling devices.
-
The Journal of pediatrics · Apr 1997
Case ReportsIntravenous ribavirin therapy in a neonate with disseminated adenovirus infection undergoing extracorporeal membrane oxygenation: pharmacokinetics and clearance by hemofiltration.
Intravenously administered ribavirin (20 mg/kg per day) was given to a neonate with disseminated adenovirus infection requiring extracorporeal membrane oxygenation and hemofiltration. Plasma concentrations at steady state were 4.81 to 8.47 micrograms/ml, hemofiltration sieving-coefficient was 0.85, and hemofiltration clearance (0.046 L/kg per hour) was similar to the renal clearance reported with normal kidney function. Despite low plasma concentrations, results of viral cultures were negative within 48 hours of initiation of ribavirin therapy, suggesting that plasma concentrations may not adequately predict inhibition of adenovirus replication in vivo.
-
The Journal of pediatrics · Apr 1997
Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection.
To determine the prevalence and temporal changes of sensorineural hearing loss (SNHL) among children with clinically inapparent (asymptomatic) congenital cytomegalovirus (CMV) infection identified from a cohort of newborn infants screened for congenital CMV infection. ⋯ Asymptomatic congenital CMV infection is likely a leading cause of SNHL in young children. The continued deterioration of hearing and delayed onset of SNHL in these children emphasizes the need for continued monitoring of their hearing status.