The Journal of pediatrics
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The Journal of pediatrics · Sep 2013
Clinical, biochemical, and neuroimaging findings predict long-term neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection.
To evaluate clinical, biochemical, and neuroimaging findings as predictors of neurodevelopmental outcome in patients with symptomatic congenital cytomegalovirus (CMV). ⋯ Adjusted head circumference, CSF β2-m level, and neuroimaging studies have prognostic significance for neurodevelopmental outcome in newborns with congenital CMV. A combination of early findings improves the predictive value.
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The Journal of pediatrics · Sep 2013
Comparative StudyIncidence of sports-related concussion among youth football players aged 8-12 years.
To determine the risk of concussion among youth football players (ages 8-12 years). ⋯ The overall IR for concussion in youth football players aged 8-12 years was comparable with that reported previously for high school and collegiate samples. However, participation in games was associated with an increase in risk of concussion compared with practices, which was higher than rates previously reported for high school and collegiate athletes. Younger players were slightly less likely to incur a concussion than were older players.
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The Journal of pediatrics · Sep 2013
Histological characteristics of the fetal inflammatory response associated with neurodevelopmental impairment and death in extremely preterm infants.
To test the hypothesis that increasing severity of the fetal inflammatory response (FIR) would have a dose-dependent relationship with severe neurodevelopmental impairment or death in extremely preterm infants. ⋯ Severe FIR, characterized by subacute necrotizing funisitis and severe chorionic plate vasculitis with thrombosis, is associated with severe neurodevelopmental impairment/death in preterm infants.
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The Journal of pediatrics · Sep 2013
Review Meta AnalysisDoes the use of antipyretics in children who have acute infections prolong febrile illness? A systematic review and meta-analysis.
To review the literature and test the hypothesis that the use of antipyretic drugs in children with acute infections slows recovery. ⋯ There is no evidence from these studies that the use of antipyretics slows the resolution of fever in children.
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The Journal of pediatrics · Sep 2013
Multicenter StudyImpact of gender on sepsis mortality and severity of illness for prepubertal and postpubertal children.
To investigate differences in sepsis mortality between prepubertal and postpubertal males and females. ⋯ Sepsis mortality is similar in prepubertal males and females. However, postpubertal males have a higher sepsis mortality than postpubertal females, likely related to their greater severity of illness on PICU admission. These outcome differences in postpubertal children may reflect a hormonal influence on the response to infection or differences in underlying comorbidities, source of infection, or behavior.