Journal of psychiatric research
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Meta Analysis
Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis.
Melatonin, a pineal gland hormone is reported to have a protective effect against delirium. This systematic review and meta-analysis explores the effect of melatonin and melatonin receptor agonist, ramelteon on delirium prevention in adult hospitalized patients. ⋯ Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and treatment duration remain uncleared and open to further studies with larger sample sizes.
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Health care workers, especially frontline nurses, faced great challenges during the coronavirus disease 2019 (COVID-19) outbreak. ⋯ The psychological status of nurses needs more attention during the COVID-19 pandemic, especially for those who fought in the frontline during the peak of the outbreak.
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Loneliness is a public health problem that is expected to rise during the COVID-19 pandemic, given the widespread policy of quarantine. The literature is unclear whether loneliness during COVID-19 is similar to those of non-pandemic seasons. This study examined the expression of loneliness on Twitter during COVID-19 pandemic, and identified key areas of loneliness across diverse communities. ⋯ The findings reflect close-to-real-time public sentiments on loneliness during the COVID-19 pandemic and demonstrated the potential usefulness of social media to keep tabs on evolving mental health issues. It also provides inspiration for potential interventions to address novel problems-such as loneliness-during COVID-19 pandemic.
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Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, is a disaster due to not only its psychosocial impact but it also to its direct effects on the brain. The latest evidence suggests it has neuroinvasive mechanisms, in addition to neurological manifestations, and as seen in past pandemics, long-term sequelae are expected. Specific and well-structured interventions are necessary, and that's why it's important to ensure a continuity between primary care, emergency medicine, and psychiatry. ⋯ A proper stratification of patients according not only to psychosocial factors but also an inflammatory panel and SARS-Cov-2's direct effects on the central nervous system (CNS) and the immune system, may improve outcomes. The complexity of COVID-19's pathology and the impact on the brain requires appropriate screening that has to go beyond the psychosocial impact, taking into account how stress and neuroinflammation affects the brain. This is a call for a clinical multidisciplinary approach to treat and prevent Sars-Cov-2 mental health sequelae.