J Clin Lipidol
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Homozygous familial hypercholesterolemia is characterized by extremely elevated serum low-density lipoprotein cholesterol (LDL-C) levels and increased risk of cardiovascular complications due to biallelic mutations in LDL receptor (LDLR). ⋯ Our report supports the role of genetic testing in the proband and the parents for accurate genetic counseling. Our patient had marked lowering of LDL-C with a combination of statin and ezetimibe but may require additional therapy.
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Randomized Controlled Trial
Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials.
Lipoprotein(a) [Lp(a)] levels are primarily genetically determined, but their natural variability is not well known. ⋯ In subjects randomized to placebo in Lp(a) lowering trials, modest intra-individual temporal variability of mean Lp(a) levels was present. Significant number of subjects had > ±25% variation in Lp(a) in at least 1 time point. Although Lp(a) levels are primarily genetically determined, further study is required to define additional factors mediating short-term variability.
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Review Meta Analysis
The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis.
Cinnamon is a rich botanical source of polyphenols, whose positive effects on blood lipid concentrations have been hypothesized, but have not been conclusively studied. ⋯ Cinnamon supplementation significantly reduced blood triglycerides and total cholesterol concentrations without any significant effect on LDL-C and HDL-C.
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Case Reports
Acute hyperlipidemic pancreatitis accompanied by chylous ascites with normal amylase and lipase in pregnancy.
Normal serum amylase is uncommon even in acute hypertriglyceridemic pancreatitis (HTGAP). However, normal serum lipase and amylase activity in HTGAP with chylous ascites is exceptionally rare. ⋯ She showed acute abdominal pain and significant systemic inflammatory response, but her serum amylase and lipase levels failed to increase, although ultrasonic imaging finding of the pancreas was normal. Early clinical recognition of chylomicronemia helps clinicians diagnose HTGAP rapidly during pregnancy.