The Journal of surgical research
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Total hip arthroplasty (THA), hemiarthroplasty (HA), and open reduction internal fixation (ORIF) are treatment options for femoral neck fractures. However, the optimal surgical treatment remains unclear. The present study aimed to describe the 30-d postoperative outcomes of THA, HA, and ORIF among patients aged ≥65 y with femoral neck fractures within a national surgical database. ⋯ No differences were found in the 30-d mortality rates among the ORIF, HA, and THA groups. ORIF and HA resulted in a lower likelihood of developing respiratory complications than THA.
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To study the effect of preoperative hyponatremia (Na <135 mEq/L) on outcomes after cardiac surgery. ⋯ Preoperative hyponatremia is common, especially in high-risk patients. It is an independent risk factor for mortality, prolonged hospitalization, and complications after cardiac surgery.
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Various animal models have been developed to investigate the complex mechanisms leading to intervertebral disc disorders and to evaluate the different therapeutic options. The needle puncture technique is commonly used to induce intervertebral degeneration in animal models. The present study aimed to establish a rabbit model of intervertebral disc degeneration using a simple, minimally invasive procedure. ⋯ A simple, but minimally invasive, intervertebral disc degeneration model was established successfully using computed tomography-guided percutaneous puncture technology in the rabbit. The puncture procedure can be performed with minimal damage and handling of the other structures, ensuring a uniform reproducible disc degeneration model.
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Therapeutic hypothermia has been proposed to protect organs in some diseases. However, the effect of therapeutic hypothermia on liver injury in sepsis is unknown. The aim of this study was to evaluate the effects of therapeutic hypothermia on liver injury in sepsis. ⋯ Therapeutic hypothermia attenuated liver injury in a polymicrobial sepsis model of rats by enhancing the Akt signaling pathway and decreasing apoptosis.
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Mechanical ventilation is a life-saving therapy for acute respiratory distress syndrome (ARDS). However, unphysiological lung stress (transpulmonary pressure) and strain (the ratio between inflated volume and functional residual capacity) can induce lung injury. Unfortunately, both stress and strain are not measured directly because of technical limitations but predicted from airway plateau pressure (Pplat) and tidal volume (Vt). Recently, some literatures indicated that Pplat and Vt cannot be good surrogates without distinguishing pulmonary ARDS patients (ARDSp) from extrapulmonary ARDS patients. Analyzing them together might distort the truth. Thus, we established animal models of ARDSp to explore whether lung stress and strain can be surrogated precisely by Pplat and Vt. ⋯ Pplat is an adequate surrogate for lung stress, but Vt cannot represent lung strain sufficiently.