Neuropsych Dis Treat
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Neuropsych Dis Treat · Jan 2013
A validation study of the Chinese-Cantonese Addenbrooke's Cognitive Examination Revised (C-ACER).
There is no valid instrument for multidomain cognitive assessment to aid the detection of mild cognitive impairment (MCI) and mild dementia in Hong Kong. This study aimed to validate the Cantonese Addenbrooke's Cognitive Examination Revised (C-ACER) in the identification of MCI and dementia. ⋯ C-ACER is a sensitive and specific bedside test to assess a broad spectrum of cognitive abilities, and to detect MCI and dementia of different severity. It can be used and interpreted with ease, without the need to adjust for education level in persons aged 60 or above.
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Neuropsych Dis Treat · Jan 2013
Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients.
Bipolar disorder (BP) is often associated with a change in hypothalamus- pituitary-adrenal axis function change due to chronic stress. Salivary α-amylase (sAA) levels increase in response to psychosocial stress and thus function as a marker of sympathoadrenal medullary system activity. However, sAA has been studied less often than salivary cortisol in BP patients. ⋯ These preliminary results suggest that sAA may be a useful biological marker for BP patients.
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Neuropsych Dis Treat · Jan 2013
Risk-benefit considerations in the treatment of relapsing-remitting multiple sclerosis.
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system and mainly affects young adults. Its natural history has changed in recent years with the advent of disease-modifying drugs, which have been available since the early 1990s. The increasing number of first-line and second-line treatment options, together with the variable course of the disease and patient lifestyles and expectations, makes the therapeutic decision a real challenge. ⋯ There is no single best treatment strategy, but therapy has to be tailored to the patient. This is a time-consuming task, rich in complexity, and influenced by the attitude towards risk on the parts of both the patient and the clinical team. The broader the MS drug market becomes, the harder it will be for the clinician to help the patient decide which therapeutic strategy to opt for.
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Neuropsych Dis Treat · Jan 2009
Excited delirium: Consideration of selected medical and psychiatric issues.
Excited delirium, sometimes referred to as agitated or excited delirium, is the label assigned to the state of acute behavioral disinhibition manifested in a cluster of behaviors that may include bizarreness, aggressiveness, agitation, ranting, hyperactivity, paranoia, panic, violence, public disturbance, surprising physical strength, profuse sweating due to hyperthermia, respiratory arrest, and death. Excited delirium is reported to result from substance intoxication, psychiatric illness, alcohol withdrawal, head trauma, or a combination of these. ⋯ Excited delirium involves behavioral and physical symptoms that are also observed in medical and psychiatric conditions such as rhabdomyolysis, neuroleptic malignant syndrome, and catatonia. A useful contribution of this communication is that it links the state of excited delirium to conditions for which there are known and effective medical and psychiatric interventions.
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Neuropsych Dis Treat · Dec 2008
Post-traumatic stress, depression, and anxiety in patients with injury-related chronic pain: A pilot study.
To investigate, in patients with injury-related chronic pain, pain intensity, levels of post-traumatic stress, anxiety and depressions. ⋯ The findings of relationships between pain intensity, post-traumatic stress, depression, and anxiety may have implications for clinicians and underline the importance of considering all these factors when managing patients with injury-related chronic pain.