The Journal of thoracic and cardiovascular surgery
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J. Thorac. Cardiovasc. Surg. · Nov 2012
Mechanical preconditioning enables electrophysiologic coupling of skeletal myoblast cells to myocardium.
The effect of mechanical preconditioning on skeletal myoblasts in engineered tissue constructs was investigated to resolve issues associated with conduction block between skeletal myoblast cells and cardiomyocytes. ⋯ We have generated skeletal myoblast-based transplantable grafts that electrically couple to myocardium.