The Journal of thoracic and cardiovascular surgery
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J. Thorac. Cardiovasc. Surg. · Feb 2019
Endothelial progenitor cells attenuate the lung ischemia/reperfusion injury following lung transplantation via the endothelial nitric oxide synthase pathway.
Endothelial progenitor cells (EPCs) can improve endothelial integrity. This study aimed to examine the effects and the mechanism of EPCs on lung ischemia-reperfusion injury (LIRI). ⋯ Data indicated that EPC ameliorated LIRI by increasing eNOS expression.
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J. Thorac. Cardiovasc. Surg. · Feb 2019
Recipient hypertonic saline infusion prevents cardiac allograft dysfunction.
Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS infusion would limit endothelial and left ventricular (LV) dysfunction following transplantation. ⋯ Recipient HTS pretreatment preserves allograft vasomotor and LV function, and HTS therapy limits CPB-induced injury. HTS may be a novel recipient intervention to prevent graft dysfunction.
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J. Thorac. Cardiovasc. Surg. · Feb 2019
Editorial CommentLoeys-Dietz: Anything special for tomorrow's case?