The Journal of thoracic and cardiovascular surgery
-
J. Thorac. Cardiovasc. Surg. · Aug 2024
Predictive Modeling of Endocardial Fibroelastosis Recurrence in Patients with Congenital Heart Disease.
Endocardial fibroelastosis (EFE) is a major effector in the maldevelopment of the heart in patients with congenital heart disease. Despite successful surgical removal, EFE can redevelop, but the underlying cause of EFE recurrence remains unknown. This study aimed to identify hemodynamic predictors and genetic links to epithelial/endothelial-to-mesenchymal transition (EMT/EndMT) alterations for preoperative risk assessment. ⋯ These findings established a predictive scoring system using preoperative hemodynamic parameters for EFE recurrence risk assessment. Alterations in HHE genes, particularly those linked to cardiac EMT/EndMT, exacerbate the risk of recurrence.
-
J. Thorac. Cardiovasc. Surg. · Aug 2024
Minimally invasive versus open esophagectomy; comparing the combined effects of smoking burden and operative approach on outcomes in esophagectomy.
To evaluate the interaction between smoking status and operative approach following esophagectomy on perioperative outcomes. ⋯ Respiratory complications and other major morbidity outcomes following esophagectomy are substantially worsened by smoking history, particularly in current smokers. Among NS, MIE is associated with reduced operative mortality.