The Journal of thoracic and cardiovascular surgery
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J. Thorac. Cardiovasc. Surg. · Nov 2024
Development of and recovery from acute kidney injury after cardiac surgery: Randomized phase 2 trial of the hepatocyte growth factor mimetic ANG-3777.
To investigate the safety and efficacy of ANG-3777, a hepatocyte growth factor mimetic, in mitigating the risk of acute kidney injury (AKI) in patients undergoing cardiac surgery with cardiopulmonary bypass. ⋯ Findings from this study do not support the efficacy of ANG-3777 in preventing the development of AKI following cardiopulmonary bypass.
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J. Thorac. Cardiovasc. Surg. · Nov 2024
Long-term outcomes in total arch replacement combined with frozen elephant trunk for acute type A aortic dissection.
The optimal surgical approach for acute type A aortic dissection (ATAAD) involving the aortic arch remains controversial. This study aims to evaluate the long-term outcomes of ATAAD treated with total arch replacement combined with frozen elephant trunk implantation (TAR with FET) in a large single-center cohort. ⋯ TAR with FET demonstrates acceptable operative mortality and promising long-term outcomes for ATAAD. Females face higher risks of operative and long-term mortality compared to males. TAR with FET provides patients with encouraging long-term quality of life and is advisable for ATAAD in experienced centers.
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J. Thorac. Cardiovasc. Surg. · Nov 2024
Revascularization after Minimally Invasive Coronary Artery Bypass Grafting in 566 Patients: Is It a Problem?
Minimally invasive coronary artery bypass grafting (MICS CABG) allows visualization and revascularization of all myocardial territories through a small anterolateral thoracotomy, with or without cardiopulmonary bypass. It is increasing in popularity as a safe and effective alternative to sternotomy CABG. In this study, we examine the correlates and long-term outcomes of repeat revascularization (RR) in MICS CABG patients. ⋯ Among 566 patients who underwent MICS CABG over a 17-year period, RR was an infrequent event affecting 8.7% of patients, with no negative impact on long-term survival.
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J. Thorac. Cardiovasc. Surg. · Nov 2024
Outcomes after hospital discharge in children requiring post-cardiotomy extracorporeal membrane oxygenation: a binational retrospective cohort study.
To describe longer-term survival and morbidity outcomes after hospital discharge in a binational cohort of children who required extracorporeal membrane oxygenation after cardiac surgery. ⋯ 38% of children who required ECMO after cardiac surgery did not survive beyond 1 year. However, of patients who survived to hospital discharge, 95% were alive at one year. Approximately 80% of patients were alive at 5 years after hospital discharge. Outcomes were poorer in patients with single ventricle physiology. 40% of patients had significant morbidity after hospital discharge.
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J. Thorac. Cardiovasc. Surg. · Nov 2024
Retrospective analysis of factors contributing to poor prognosis among 271 pediatric patients with tracheal stenosis treated with slide tracheoplasty.
To determine factors contributing to adverse postsurgical outcomes in children with congenital tracheal stenosis (CTS) treated with slide tracheoplasty (STP). ⋯ Careful assessment and management of perioperative conditions are essential to minimize risk of adverse postsurgical outcomes in CTS patients undergoing STP.