The Journal of thoracic and cardiovascular surgery
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J. Thorac. Cardiovasc. Surg. · Nov 2014
Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction.
The aim of the present study was to construct a new drug delivery system for milrinone using microparticles. This novel technology enhances drug bioavailability and decreases toxicity, with future implications for the treatment of end-stage heart failure. ⋯ Drug encapsulation using microparticles can prolong the effects of milrinone. We propose a new strategy for future drug delivery in patients with end-stage heart failure.
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J. Thorac. Cardiovasc. Surg. · Nov 2014
Review Meta AnalysisMeta-analysis of minimally invasive coronary artery bypass versus drug-eluting stents for isolated left anterior descending coronary artery disease.
To compare the outcomes between minimally invasive coronary artery bypass (MINI-CAB) and drug-eluting stent (DES) implantation for isolated left anterior descending artery disease. ⋯ Given the available evidence, MINI-CAB will result in lower target vessel revascularization rates but otherwise similar clinical outcomes compared with DESs in patients with left anterior descending artery disease.
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J. Thorac. Cardiovasc. Surg. · Nov 2014
Review Meta AnalysisMitral valve surgery: right lateral minithoracotomy or sternotomy? A systematic review and meta-analysis.
To update the current evidence on mitral valve surgery through a lateral minithoracotomy versus median sternotomy. ⋯ MIVS and conventional mitral valve surgery have a similar perioperative outcome. Mitral valve surgery via a right lateral minithoracotomy seems to be favorable with regard to resource-related outcome.