The Journal of thoracic and cardiovascular surgery
The most recent articles from:
J. Thorac. Cardiovasc. Surg.
-
J. Thorac. Cardiovasc. Surg. · Sep 2024
Therapeutic potential of human iPS cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device.
This study aimed to explore the therapeutic potential of human induced pluripotent stem cell (hiPSC)-derived cardiac tissues (HiCTs) in the emerging approach of bridge to recovery for severe heart failure with ventricular assist devices. We used a rat model of heterotopic heart transplantation (HTx) to mimic ventricular assist device support and heart unloading. ⋯ Transplanting HiCTs into ischemic hearts under unloaded conditions promoted engraftment, neovascularization, attenuated infarct remodeling, and suppressed myocyte atrophy. These results suggest that HiCT treatment could contribute to future advancements in bridge to recovery.