Zh Nevrol Psikhiatr
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An aim of the study was to assess clinical-economic effectiveness of therapy in the stages of examination of an epileptic patient by a local neurologist and then by an epileptologist after therapy optimization. Three hundreds and ten patients with different forms of epilepsy and types of epileptic seizures were treated. ⋯ The expenses for treatment were compared to treatment effectiveness. It is concluded that mean costs of treatment of epilepsy, including new brands of antiepileptic drugs with high prices, have substantial medical-social benefits that compensate expenses for their purchasing at the expense of other direct and indirect costs.
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Zh Nevrol Psikhiatr · Jan 2010
Controlled Clinical Trial[Efficacy and safety of rivastigmine (exelon) in the confusion syndrome in the acute phase of ischemic stroke].
There is ample evidence that the poststroke confusion syndrome or delirium is a manifestation of cholinergic deficit. Given this conception, we conducted a controlled study of efficacy and safety of acetylcholinesterase inhibitor rivastigmine in patients developed a delirium in the acute phase of ischemic stroke. The study included 224 consecutive stroke patients: 68 patients developed a delirium in the acute phase of disease. ⋯ Total ZBI scores were more favorable in the rivastigmine group than in the control one (p<0,05). To the end of the study, 5 patients died in the rivastigmine group, 17 patients in the control group and 3 patients in the group without delirium. Rivastigmine was safe in the acute phase of stroke patients even after the rapid titration.
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Zh Nevrol Psikhiatr · Jan 2010
[Levels of S100β protein in patients with mild traumamic brain injury].
The prospective study of plasma S100β protein levels in 19 patients with mild traumamic brain injury treated with conservative methods was carried out. The S100β protein levels were measured on the admission of the patient and after 24 and 48 h. The level of S100β increased above normal values (>0,105 mkg/l) in 11 patients (58%) in the first 6 h after the trauma. ⋯ CT revealed brain lesions in 73% and MRI in 100% of patients with mild traumamic brain injury and increased plasma S100β levels. There was no correlation between the S100β level and the type of brain lesion, its localization or volume and the fracture of cranial bones. Also, no correlation was found between S100β levels and EEG changes (p>0,05).