Zh Nevrol Psikhiatr
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Zh Nevrol Psikhiatr · Jan 2011
Controlled Clinical Trial[Efficacy of gabapentin in the treatment of professional polyneuropathy].
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Zh Nevrol Psikhiatr · Jan 2011
[Characteristics of ischemic stroke in patients with congenital anomalies of the circle of Willis].
The study included 76 patients with ischemic stroke in the carotid system (56 patients) and in the vertebrobasilar system (20 patients). The magnetic resonance angiography (MRA) revealed congenital anomalies of Willis circle in 31 patients. These anomalies were stratified as follows: back trifurcation of the internal carotid artery (ICA) (19 patients), anterior trifurcation of the ICA (4 patients), the combination of anterior trifurcation of the one of ICA and posterior trifurcation of the other ICA (4 patients), double back trifurcation of ICA (2 patients), the normal structure of the circle of Willis (45 patients). ⋯ Despite the lack of significant differences in the size of lesions in 2 groups, the foci in patients with the abnormalities of the circle of Willis were frequently localized in adjacent blood supply zones. The signs of vascular encephalopathy were seen as well. The data obtained suggest that the presence of anomalies in the circle of Willis is a risk factor, together with in the additional adversities, including iatrogenic factor, for the development of hemodynamic ischemic stroke.
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Zh Nevrol Psikhiatr · Jan 2011
[Prediction of outcomes of moderate and severe brain injury and cerebral trauma in victims evacuated from the warfare].
The aim was to estimate predictors and prognostic models of the nearest outcomes in moderate and severe traumatic brain injury. Authors have analyzed 75 medical histories of patients with moderate and severe traumatic brain injury. ⋯ The results obtained confirm the prognostic value of the Glasgow coma scale. The additional account of the indicators characterizing the expression of inflammatory processes and organ insufficiency allows to significantly improve the prognostic models of outcomes in patients with traumatic brain injury.
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Zh Nevrol Psikhiatr · Jan 2011
[The state of nociceptive and antinociceptive brain systems in patients with the pain form of diabetic polyneuropathy].
We studied 48 patients with the pain form of distal symmetric sensorimotor diabetic polyneuropathy (DPN) before and after polytherapy and 17 sex- and age-matched healthy people. Clinical/neurological, psychometric and neurophysiologic (recording of nociceptive flexor reflex (NFR) and exteroceptive suppression of involuntary muscle activity) methods were used. ⋯ The significant reduction of pain, increase of NFR thresholds and Pt/Rt coefficients were seen after the treatment with antidepressants (venlafaxine or pipofezine) in the combination with carbamazepine that suggests the strengthening of supraspinal and antinociceptive systems activity. Measuring of NFR parameters has a practical value for the assessment of the state of antinociceptive brain systems, intensity of pain syndrome, severity of comorbid anxiety-depression disorders and for the objectification of treatment efficacy in patients with DPN.