Zh Nevrol Psikhiatr
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Zh Nevrol Psikhiatr · Jan 2006
Randomized Controlled Trial Multicenter Study[A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke].
To study the efficacy and safety of tolperisone--a centrally acting muscle relaxant with membrane stabilizing activity--in the treatment of stroke-related spasticity. This was a randomized, double-blind, placebo-controlled, multicenter study with parallel groups. Treatment lasted 12 weeks and was started with a titration period of variable length (dose range 300-900 mg tolperisone daily). ⋯ No withdrawals caused by adverse events were reported in the tolperisone group. The findings of the present study demonstrate the efficacy and excellent tolerance of tolperisone in the treatment of spastic hypertonia following cerebral stroke. Study data further suggest that an individual dose titration which may exceed the recommended maximum dose of 450 mg daily results in optimized therapeutic benefit.
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Zh Nevrol Psikhiatr · Jan 2006
[Electroneuromyographic study of the median nerve: peculiarities of M-response from the anterior forearm muscles during stimulation of the brachial plexus].
Motor fibers of the median nerve innervating the anterior forearm muscles during stimulation of the brachial plexus have been studied. A role of forearm muscles innervated by the cubital and radial nerves in the formation of the M-response recorded from the anterior forearm muscles has been determined. Surface stimulating and recording electrodes have been used, with the active recording electrode being placed on the border between the upper and the middle one third of the anterior forearm surface and the reference electrode--in the area of the lower one third of the forearm. ⋯ The radial nerve also exerts a significant influence on development of the M-response. A role of the cubital nerve is minimal (p>0.05). The M-response recorded from the anterior forearm surface during brachial plexus stimulation is a result of summed potentials of motor units both of the anterior forearm muscles innervated by the median and cubital nerves and of the lateral and posterior groups innervated by the radial nerve.