Zh Nevrol Psikhiatr
-
Zh Nevrol Psikhiatr · Jan 2005
Comparative Study[Interferons beta in patients with multiple sclerosis].
-
Zh Nevrol Psikhiatr · Jan 2004
Comparative Study[Influence of long-term quetiapine (Seroquel) and haloperidol therapy on cognitive deficit in patients with paranoid schizophrenia].
In of 67 patients with ICD-10 diagnosis of paranoid schizophrenia compared influence of atypical neuroleptic Seroquel (31 patients) and typical neuroleptic haloperidol (36 patients) on cognitive disturbances. The latter were evaluated using 8 neuropsychological tests and clinical symptoms were measured by the PANSS. There were 39 patients with the first episode and 28 with a chronic disease course. ⋯ Cognitive functions related to positive symptoms (attention, verbal memory) improved in both groups. Seroquel positively affected motor functions. The study confirmed the earlier reports on possibility of neurocognitive deficit correction by atypical antipsychotic drugs in the first episode as well as in chronic patients with schizophrenia.
-
Zh Nevrol Psikhiatr · Jan 2003
Case Reports[Neurological disturbances in heroin addicts in acute withdrawal and early post-abstinence periods].
Neurological examination was performed in 79 heroin addicts (mean age 24.4 +/- 6.3 years; heroin abusing duration 16.6 +/- 12.4 months; heroin dose per day 0.48 +/- 0.42 grams). During the first week after withdrawal, "physical dependency" symptoms, mild hypomimia and hypokinesia, low muscle tone, low tendon reflexes and facilitated nociceptive reflexes were observed in more than 70% of the patients. Non-specific microneurological signs as nystagm, limited convergence, tremor and dynamic ataxia etc, were found in more than 35% of the cases. ⋯ The most abundant neurological disturbances were observed in patients abusing heroin for more than 6 months in dosages more than 0.4 grams per day. Heroin withdrawal symptoms include reversible decrease in muscle tone and tendon reflexes as well as facilitation of nociceptive reflexes and reversible non-specific neurological microsigns. Heroin encephalopathy is characterized by ventral striatum insufficiency signs.
-
Based on the literature and their own observations of 44 children aged 5-15 years (27 girls, 17 boys) with prior strokes, the authors characterize the types of strokes and principle causes of the disease as follows: (1) intracerebral and subarachnoidal hemorrhages (key etiology--arteriovenous malformations, blood disorders, coagulopathy, thrombocytopenias, thrombocytopathy, etc.) and (2) ischemic strokes i.e. (i) thrombotic (congenital and acquired vascular aplasias, angiitis, antiphospholipoid and viral vasculopathy, blood system coagulate activation, etc.); (ii) embolic (cardiogenic, septic, placental, etc.) and (iii) hemodynamic as a consequence of severe cardiomyopathy and disrupted total hemodynamics. The definitions of metabolic stroke as a complication of mitochondrial encephalopathy, homocystinuria and non-differentiated stroke caused more often by emergence of pathologic weariness of connective tissues were suggested. To elicit the stroke causes and types in children, the authors propose a reliable algorithm for clinico-instrumental diagnostic screening in acute period of stroke.