Neuroendocrinol Lett
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Neuroendocrinol Lett · Jan 2011
Central diabetes insipidus is not a common and prognostically worse type of hypernatremia in neurointensive care.
Hypernatremia is a common sodium dysbalance in neurointensive care which is associated with worse outcome. It can be caused by central diabetes insipidus (cDI) or by other mechanisms, more often from osmotherapy and furosemide. The aim of this study was to determine the incidence of cDI and to analyse outcome as compared with other causes of hypernatremias found in neurointesive care. ⋯ Central diabetes insipidus is not a frequent type of hypernatremia in neurointensive care. Prognosis is connected with serum sodium level, not with type of hypernatremia.
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Neuroendocrinol Lett · Jan 2011
Comparative StudyCodeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
There is good evidence that opioids can potentiate analgesic activity of some older non-opioid analgesics (such as paracetamol or ibuprofen) but it is not known whether this also holds true for newer non-opioid analgesics that selectively inhibit cyclooxygenase 2 (coxibs). This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice. For comparison, interactions of codeine with paracetamol and ibuprofen were also tested using the same method. ⋯ These and other results suggest that opioids do not seem to potentiate analgesic effects of selective COX-2 inhibitors, in contrast to nonselective COX inhibitors or paracetamol.
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Neuroendocrinol Lett · Jan 2011
Estrogen altered facial mechanical pain threshold and trigeminal P2X3 receptor expression.
P2X3 receptors are expressed in trigeminal ganglia (TG) and participate in the transduction of facial pain. However, the mechanisms underlying P2X receptor-mediated nociception at different estrogen levels has not been examined. ⋯ These results indicate that estrogen might modulate the transduction of facial pain by inhibiting P2X3 receptor in TG.