Neuroendocrinol Lett
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Neuroendocrinol Lett · Jan 2011
Case ReportsTransverse testicular ectopia with abnormal karyotype - a case report.
Growth disturbances and developmental malformations of external genitalia, such as hypospadias, bifid scrotum and micropenis, coexisting with non-palpable testes, may develop as a result of primary endocrinological dysfunctions as well as an effect secondary to chromosomal aberrations. Therefore, patients with these symptoms require specific diagnostic and therapeutic approaches. ⋯ The presence of mosaic karyotype with abnormal Y chromosome does not exclude a possibility of testis migration disorders, including TTE, caused by other (possibly genetic) factors. Laparoscopy is a technique of choice for diagnosis and treatment in cases of cryptorchidism.
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Neuroendocrinol Lett · Jan 2011
Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholinesterase (AChE) such as rivastigmine, galantamine and donepezil. As huperzine is a promising compound for AD treatment, our study was aimed at evaluating its pertinent implications in oxidative stress. ⋯ We discuss the potency of huperzine in enhancing the antioxidant capacity of the central nervous system. Huperzine is probably implicated in more processes than cholinesterase inhibition only.
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Neuroendocrinol Lett · Jan 2011
Estrogen altered facial mechanical pain threshold and trigeminal P2X3 receptor expression.
P2X3 receptors are expressed in trigeminal ganglia (TG) and participate in the transduction of facial pain. However, the mechanisms underlying P2X receptor-mediated nociception at different estrogen levels has not been examined. ⋯ These results indicate that estrogen might modulate the transduction of facial pain by inhibiting P2X3 receptor in TG.