Jpen Parenter Enter
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Jpen Parenter Enter · Jan 2013
Case ReportsA rare case of hyperammonemia complication of high-protein parenteral nutrition.
Hyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late-onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28-year-old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.
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Jpen Parenter Enter · Jan 2013
Obesity is not associated with increased mortality and morbidity in critically ill children.
To evaluate the effect of obesity on mortality, length of mechanical ventilation, and length of stay (LOS) in critically ill children. ⋯ Critically ill overweight, obese, and severely obese children who require invasive mechanical ventilation have similar mortality, length of stay in the PICU, and ventilator days as compared with normal-weight children.
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Jpen Parenter Enter · Nov 2012
Randomized Controlled Trial Comparative StudyMarkers of inflammation and coagulation may be modulated by enteral feeding strategy.
Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown. ⋯ EN strategy in critically ill patients with acute respiratory failure does not significantly modify inflammation and coagulation by day 6, but trophic feeds may have some modest effects in attenuating inflammation and coagulation.