Jpen Parenter Enter
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Concentrations of triglycerides (TG) and cholesterol in serum and in lipoproteins were determined in two groups of intensive care patients. Group I included 17 moderately ill, postelective surgery patients, and group II, 23 critically ill patients. All were studied in an intensive care situation. ⋯ The time effect on lipoprotein changes was analyzed in 11 patients, from whom samples were drawn repeatedly during the intensive care period. A tendency was found for LDL-TG to increase and HDL-cholesterol to decrease with time. The mechanisms causing the lipoprotein changes are not presently known; however, possible explanations include liver function impairment, gastrointestinal tract paralysis, physical inactivity, the catabolic state as such, and combinations.
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Jpen Parenter Enter · Sep 1982
Effects of intravenous administration of Travenol 10% lipid emulsion to miniature swine for 28 consecutive days.
The potential toxicity of Travenol 10% lipid emulsion was studied using miniature swine. Physiological (0.9%) saline, USP, was used as the control, and Intralipid 10% fat emulsion as the reference article. The emulsions were administered intravenously at dosages of 40 milliliters (approximately 4 grams of lipid) and 60 milliliters (approximately 6 grams of lipid) per kilogram of body weight per day to eight animals (four males and four females) in each treatment group on each of 28 consecutive days. ⋯ All Travenol emulsion-treated animals survived. In addition to demonstrating the similarity of Travenol and Intralipid emulsions, the results of this study indicate that the Travenol emulsion demonstrated an adequate margin of safety for prolonged administration. Travenol emulsion was well tolerated by miniature swine infused at about one and one-half (40 milliliters per kilogram per day) and two (60 milliliters per kilogram per day) times the proposed clinical dose, and at three and two times the anticipated clinical rate, respectively.