Pediatr Crit Care Me
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Pediatr Crit Care Me · Oct 2013
Randomized Controlled Trial Multicenter StudyAltered Circulating Leukocytes and Their Chemokines in a Clinical Trial of Therapeutic Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy*
To determine systemic hypothermia's effect on circulating immune cells and their corresponding chemokines after hypoxic ischemic encephalopathy in neonates. ⋯ Our data are consistent with chemokine-associated systemic immunosuppression with hypothermia treatment. In hypothermic neonates, persistence of lower leukocyte counts after rewarming is observed in infants with more severe CNS injury.
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Pediatr Crit Care Me · Oct 2013
Multicenter StudyDifferences in Medical Therapy Goals for Children With Severe Traumatic Brain Injury-An International Study.
To describe the differences in goals for their usual practice for various medical therapies from a number of international centers for children with severe traumatic brain injury. ⋯ There were marked differences in medical goals for children with severe traumatic brain injury across our international consortium, and these differences seemed to be greatest in areas with the weakest evidence in the literature. Future studies that determine the superiority of the various medical therapies outlined within our survey would be a significant advance for the pediatric neurotrauma field and may lead to new standards of care and improved study designs for clinical trials.
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Pediatr Crit Care Me · Oct 2013
Multicenter StudyHospitalizations of Children With Neurologic Disorders in the United States.
Although neurologic disorders are among the most serious acute pediatric illnesses, epidemiologic data are scarce. We sought to determine the scope and outcomes of children with these disorders in the United States. ⋯ Children with neurologic diagnoses account for a disproportionate amount of ICU stays and deaths compared with children hospitalized for other reasons.
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Pediatr Crit Care Me · Oct 2013
Early Lactate Elevations Following Resuscitation From Pediatric Cardiac Arrest Are Associated With Increased Mortality*
To describe the association of lactate levels within the first 12 hours after successful resuscitation from pediatric cardiopulmonary arrest with hospital mortality. ⋯ Elevated lactate levels in the first 12 hours after successful resuscitation from pediatric cardiac arrest are associated with increased mortality. Lactate levels alone are not able to predict outcomes accurately enough for definitive prognostication but may approximate mortality observed in this large cohort of children's hospitals.
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Pediatr Crit Care Me · Oct 2013
Observational StudyAssociation of Human Beta-Defensin-2 Serum Levels and Sepsis in Preterm Neonates*
To determine human beta-defensin-2 levels in term and preterm neonates at birth and to evaluate its impact on sepsis. ⋯ Preterm neonates show lower human beta-defensin-2 levels in cord blood compared with term neonates. Low human beta-defensin-2 levels in preterm neonates might be associated with an increased risk of late-onset sepsis.