Pediatr Crit Care Me
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To report our experience with the use of IV enoxaparin in neonatal and pediatric patients in the ICU. ⋯ The pharmacodynamics of a 30-minute IV enoxaparin infusion was found to produce therapeutic 4 hour anti-Factor Xa levels similar to subcutaneous doses. Although this was a small study, there were no adverse events, suggesting the safety profile of IV enoxaparin may be similar to subcutaneous dosing with the added benefit of less pain associated with IV dosing. These findings suggest that IV enoxaparin may be a viable option for anticoagulating critically ill children and its use warrants further study.
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Pediatr Crit Care Me · Feb 2014
Ultrasound-Guided Left Brachiocephalic Vein Cannulation in Children With Underlying Bleeding Disorders: A Retrospective Analysis.
To evaluate the safety and effectiveness of ultrasound-guided left brachiocephalic vein cannulation in infants and children with underlying bleeding conditions. ⋯ Data reported in this retrospective study confirm the safety and effectiveness of ultrasound-guided left brachiocephalic vein catheterization in infants and children with underlying bleeding disorders.
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Pediatr Crit Care Me · Feb 2014
Effectiveness of a Clinical Pathway With Methadone Treatment Protocol for Treatment of Neonatal Abstinence Syndrome Following In Utero Drug Exposure to Substances of Abuse.
To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway. ⋯ Clinical pathway for treating neonatal abstinence syndrome was closely followed at the initial diagnosis. The doses of methadone used in the first 24-48 hours of this study were insufficient for adequate symptom control. Despite a formal treatment protocol, there was substantial variability in total methadone exposure, length of treatment, and length of stay, suggesting other contributory factors for the observed variability.