Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2022
Observational StudyImpact of Blood Sampling on Anemia in PICU: A Prospective Cohort Study.
Fifty percent of children are anemic after a critical illness. Iatrogenic blood testing may be a contributor to this problem. The objectives of this study were to describe blood sampling practice in a PICU, determine patient factors associated with increased sampling, and examine the association among blood sampling volume, anemia at PICU discharge, and change in hemoglobin from PICU entry to PICU discharge. ⋯ Diagnostic blood sampling in PICU is associated with anemia at discharge. Twenty-five percent of blood losses from sampling is wasted. Volumes are highest for patients with sepsis, shock, or cardiac surgery, and in patients with vascular access or ventilatory support.
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Pediatr Crit Care Me · Jun 2022
Multicenter Study Observational StudyHealth Resource Use in Survivors of Pediatric Septic Shock in the United States.
To evaluate postdischarge health resource use in pediatric survivors of septic shock and determine patient and hospitalization factors associated with health resource use. ⋯ Children with septic shock represent a high-risk cohort with high-resource needs after discharge. Interventions and targeted outcomes to mitigate postdischarge resource use may differ based on patients' preexisting conditions.
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Pediatr Crit Care Me · Jun 2022
Observational StudyAssociation Between Heart Rate Variability and Inflammatory Biomarkers in Critically Ill Children.
The autonomic nervous system (ANS) can both modulate and be modulated by the inflammatory response during critical illness. We aimed to determine whether heart rate variability (HRV), a measure of ANS function, is associated with proinflammatory biomarker levels in critically ill children. ⋯ HRVi is inversely correlated with IL-6, IL-8, and CRP. Further studies are needed to validate this measure as a proxy for a proinflammatory state.
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Pediatr Crit Care Me · Jun 2022
Multicenter StudyLactate, Base Excess, and the Paediatric Index of Mortality: Exploratory Study of an International, Multicenter Dataset.
To investigate the relationship between ICU admission blood lactate, base excess, and ICU mortality and to explore the effect of incorporating blood lactate into the Pediatric Index of Mortality. ⋯ At PICU admission, blood lactate is more strongly associated with ICU mortality than absolute base excess. Adding lactate into the Pediatric Index of Mortality model may result in a small improvement in performance. Any improvement in Pediatric Index of Mortality performance must be balanced against the added burden of data capture when considering potential incorporation into the Pediatric Index of Mortality model.