Pediatr Crit Care Me
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Pediatr Crit Care Me · Sep 2008
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age.
Age influences outcome of sepsis and septic shock. The mechanism of this age-dependent vulnerability to sepsis remains largely unknown. Because much of the mortality and morbidity associated with sepsis and septic shock is the result of severe derangements in the cardiovascular system, it is possible that the myocardium responds to injury in a developmentally influenced manner. We hypothesized that analysis of cardiac RNA expression profiles may differentiate between the myocardial response to sepsis in young and old mice. ⋯ This report describes the transcriptional response of the heart to sepsis. In addition, our findings suggest that these differences are in part age-dependent and serve as hypothesis generation.
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Pediatr Crit Care Me · Sep 2008
Implications of thrombocytopenia and platelet course on pediatric intensive care unit outcomes.
Thrombocytopenia has been shown to be an independent predictor of mortality and prolonged hospital length of stay in critically ill adults. Studies are lacking in the pediatric intensive care unit population. We evaluated the relationship between platelet counts at admission, platelet course, and outcomes. ⋯ Thrombocytopenia and falling platelet counts are associated with increased risk of mortality and length of stay in the pediatric intensive care unit.
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Pediatr Crit Care Me · Sep 2008
Randomized Controlled Trial Multicenter StudyPost hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials.
To assess the impact of calfactant (a modified natural bovine lung surfactant) in immunocompromised children with acute lung injury and to determine the number of patients required for a definitive clinical trial of calfactant in this population. ⋯ These preliminary data suggest a potential benefit of calfactant in this high-risk population. A clinical trial powered to appropriately assess these findings seems warranted and feasible.
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Pediatr Crit Care Me · Sep 2008
ReviewA comprehensive review of pediatric endotracheal suctioning: Effects, indications, and clinical practice.
To provide a comprehensive, evidence-based review of pediatric endotracheal suctioning: effects, indications, and clinical practice. ⋯ Endotracheal suctioning is a procedure used regularly in the pediatric intensive care unit. Despite this, good evidence supporting its practice is limited. Further, controlled clinical studies are needed to develop evidence-based protocols for endotracheal suctioning of infants and children, and to examine the impact of different suctioning techniques on the duration of ventilatory support, incidence of nosocomial infection, and length of pediatric intensive care unit and hospital stay.
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Pediatr Crit Care Me · Sep 2008
Randomized Controlled TrialA prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure.
To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs. standard therapy alone in children with acute respiratory failure; assess method effectiveness in improving gas exchange and vital signs; and assess method safety. ⋯ NIV improves hypoxemia and the signs and symptoms of acute respiratory failure. NIV seems to afford these patients protection from endotracheal intubation.