Psychosomatic medicine
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Psychosomatic medicine · May 2003
Review Meta AnalysisImpact of depression on experimental pain perception: a systematic review of the literature with meta-analysis.
This systematic review and meta-analysis was performed to examine the impact of depression on the perception of experimental pain stimuli. ⋯ Depressed subjects are less likely to perceive a sensory stimulus as being painful compared with nondepressed controls. The influence of depression on attention to the pain stimulus may account for this effect. More studies are required to enable us to determine the impact of depression on absolute sensory perception threshold and pain tolerance. Furthermore, more studies would enable the examination of depression on the perception of different modalities.
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Psychosomatic medicine · Jul 1998
Meta AnalysisDo antidepressants have an analgesic effect in psychogenic pain and somatoform pain disorder? A meta-analysis.
A significant amount of evidence indicates that some antidepressants have an analgesic effect. We wished to determine whether this analgesic effect could be demonstrated in studies that had used antidepressants for the treatment of pain in patients diagnosed with psychogenic pain or somatoform pain disorder. Meta-analysis was used for this purpose. ⋯ The results indicate that, in patients diagnosed with psychogenic pain or somatoform pain disorder, antidepressant treatment resulted in a reduction in pain that was significantly greater than that of placebo. Possible explanations for these results are discussed.