Crit Care Resusc
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Objective: To assess for the presence of a correlation between lung ultrasound score (LUSS) and ratio between arterial partial pressure of oxygen (PaO2) and the fraction of inspired oxygen (FiO2) in patients presenting to an emergency department (ED) with interstitial syndrome (IS). Design: Prospective, multicentre, physiological study. Setting: Four Belgian hospitals: one tertiary academic centre and three secondary centres. ⋯ Conclusions: Our data provide evidence of a statistically significant negative linear correlation between PaO2/FIO2 and LUSS for ED patients with lung IS. Given the representativeness of PaO2/FIO2 for hypoxaemia and the fact that hypoxaemia indicates IS severity, our findings suggest that LUSS could contribute to the evaluation of IS severity. If confirmed by future studies that include patient follow-up, a noninvasive approach using LUSS could decrease the need for ABG analysis in patients who do not require repeated measurement of ABG values other than PaO2, and thereby improve patient comfort.
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Objective: To evaluate the performance of cystatin C as a prognostic and predictive marker in a trial of patients with acute respiratory distress syndrome (ARDS). Design, patients and setting: A retrospective analysis was performed on plasma samples from patients included in the HARP-2 (hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction) trial - a multicentre, phase 2b trial carried out in general intensive care units across 40 hospitals in the United Kingdom and Ireland. Cystatin C concentrations in plasma obtained from 466 patients with ARDS (before they were randomly assigned in the trial) were quantified by ELISA (enzyme-linked immunosorbent assay). ⋯ In a multivariate analysis, hyperinflammatory ARDS was predictive of a beneficial effect of simvastatin on mortality (OR, 2.05 [95% CI, 1.16-3.62]; P = 0.014) but cystatin C concentration was not (OR, 1.10 [95% CI, 0.77-1.56]; P = 0.614). Conclusion: The association between cystatin C concentration and mortality in ARDS may be dependent on inflammatory subphenotype. Cystatin C concentration does not appear to add to existing prognostic or predictive approaches.
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Objectives: To investigate the prevalence and features of self-reported burnout among intensivists working in Australia and New Zealand, and evaluate potentially modifiable workplace stressors associated with increased risk of self-reported burnout. Methods: We performed an electronic survey among registered intensivists in Australia and New Zealand. Burnout and professional quality of life were measured using the Professional Quality of Life Scale version 5 (ProQOL-5). ⋯ Conclusion: Fewer Australian and New Zealand intensivists experienced burnout than previously reported. Many self-reported work stressors do not relate to clinical work and are due to interpersonal interactions with other colleges and hospital administrators. Such factors are potentially modifiable and could be the focus of future interventions.