Crit Care Resusc
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Randomized Controlled Trial
Statistical analysis plan for the Augmented versus Routine Approach to Giving Energy Trial (TARGET).
The Augmented versus Routine Approach to Giving Energy Trial (TARGET) is a 4000-patient randomised, double-blind controlled trial designed to evaluate whether enteral delivery of recommended energy goals using a 1.5 kcal/mL enteral nutrition formulation improves clinical outcomes, compared with a 1 kcal/mL enteral nutrition formulation delivered at the same goal rate, in critically ill patients receiving invasive mechanical ventilation. ⋯ We have developed a pre-specified statistical analysis plan for TARGET. To minimise analytical bias, this plan has been developed and made available to the public domain before completing recruitment and data collection.
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Randomized Controlled Trial
Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX).
The balance of risks and benefits of conservative v standard care oxygen strategies for patients who are invasively ventilated in the intensive care unit (ICU) is uncertain. ⋯ ICU-ROX will compare the effect of conservative v standard oxygen therapy in critically ill mechanically ventilated adults who are expected to be ventilated beyond the day after recruitment on ventilatorfree days to Day 28.
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Randomized Controlled Trial
A randomised controlled trial to determine the effectiveness of a radial arterial catheter dressing.
To reduce radial arterial catheter failure in patients admitted to an adult intensive care unit (ICU). ⋯ This study showed a statistically significant reduction in arterial catheter failure using a radial arterial catheter dressing of a polyurethane adhesive keyhole dressing together with a polyurethane semipermeable transparent dressing. The nursing care technique of applying this dressing may improve dressing efficacy and patient safety and reduced costs.
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Randomized Controlled Trial
Evaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate.
To determine if faster blood flow rate (BFR) has an effect on solute maintenance in continuous renal replacement therapy. ⋯ Faster BFR did not affect solute control in patients receiving CRRT; however, differences in urea and creatinine concentrations were influenced by serum haemoglobin and hours of treatment.
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Observational Study
Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model.
Intensive care unit (ICU) patients with acute kidney injury (AKI) who recover kidney function within 28 days experience less severe chronic kidney impairment and have increased long term survival. The aims of this study were to develop and validate a risk prediction model to identify these patients. ⋯ We constructed and validated a simple model that can predict the chance of recovery from AKI in critically ill patients.