Clin Exp Rheumatol
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Randomized Controlled Trial Multicenter Study
Effects of the oral Janus kinase inhibitor tofacitinib on patient-reported outcomes in patients with active rheumatoid arthritis: results of two Phase 2 randomised controlled trials.
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we investigated the effects of tofacitinib on patient-reported outcomes (PRO) in patients with active RA. ⋯ In patients with active RA, tofacitinib, either in combination with methotrexate or as monotherapy, demonstrated rapid and sustained improvement in pain, physical functioning and health-related quality of life.
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To investigate the reliability and validity of the Spanish version of the Fibromyalgia Rapid Screening Tool (FiRST), a brief questionnaire for the detection of fibromyalgia (FM) in patients with diffuse chronic pain seen at primary care health centres. ⋯ FiRST questionnaire is a useful tool for the detection of FM in primary care health centres.
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Randomized Controlled Trial Multicenter Study
Burden of illness in fibromyalgia patients with comorbid depression.
To assess the burden of fibromyalgia (FM) in patients with FM taking antidepressant medication for comorbid depression. ⋯ This study demonstrates the significant burden of FM in patients with comorbid depression treated with an antidepressant.
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Clinical features of primary Sjögren's syndrome (pSS) overlap with those of fibromyalgia (FM). This cross-sectional study was conducted to investigate the prevalence of FM in pSS patients and to compare the clinical features of pSS patients with FM to those without FM. ⋯ Our study showed that FM was prevalent in pSS. FM was associated with higher ESSPRI and more severe depression.
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To investigate the reliability and validity of the Spanish version of the 2010 American College of Rheumatology (ACR) Preliminary Diagnostic Criteria for Fibromyalgia (FM) in patients with chronic pain. ⋯ Our results indicate that the 2010 ACR Preliminary Diagnostic Criteria for FM may be useful to establish a diagnosis of FM in Spanish individuals with chronic pain.