Gastroent Hepat Barc
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Metastatic Crohn's disease is a granulomatous cutaneous lesion that appears in patients with Crohn's disease and is located in any skin area, separated from the lesions in the gastrointestinal tract. This entity is characterized by its heterogeneous behavior, both in its localization and clinical expression and in its effect on patients' quality of life. Histology is essential for diagnosis and shows non-caseating granulomas. ⋯ In most patients, treatment with biological agents is highly effective. We describe three cases of metastatic Crohn's disease with the aim of analyzing the characteristics of this entity, which should always be included in the differential diagnosis of skin lesions in patients with Crohn's disease. A literature review is also provided.
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In the last few years, much progress has been made in the diagnosis and treatment of hepatocellular carcinoma (HCC). Due to these advances, HCC is no longer regarded as a disease with an extremely poor prognosis and has become the focus of some of the most active basic and clinical research in recent years. ⋯ This increased survival has demonstrated that these drugs, which act selectively on the molecular pathways involved in tumoral progression, can be effective in the treatment of HCC and has opened the door to the evaluation of these molecular agents, alone or in combination, in HCC. The present article provides a review of the treatment of advanced-stage HCC, with special emphasis on the distinct agents that are currently under evaluation.
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Gastroent Hepat Barc · Feb 2010
Case Reports[Rupture of a pyogenic liver abscess: a rare cause of pneumoperitoneum].
Spontaneous pneumoperitoneum is a common finding in patients with abdominal disorders. In 90% of cases, this entity results from hollow viscera perforation. ⋯ Pneumoperitoneum secondary to intraperitoneal rupture of an abscess is extremely rare and very few cases have been reported in the literature. Given its clinical interest, we report a case of pneumoperitoneum due to spontaneous rupture of a gas-containing pyogenic liver abscess.