Arch Dermatol
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To determine the efficacy of ultrasonography for the diagnosis of subcutaneous benign lesions. ⋯ Ultrasonography significantly increased the preoperative diagnostic yield of subcutaneous benign lesions (after palpation, 29%; after ultrasonography, 46%; P < .001). The sensitivity for the diagnosis of lipoma (after palpation, 54.8%; after ultrasonography, 88.1%; P < .01) and the specificity for the diagnosis of epidermal cyst (after palpation, 93.5%; after ultrasonography, 99.3%; P < .05) significantly increased after ultrasonography. The sensitivity for the diagnosis of epidermal cyst and ganglion also tended to increase after ultrasonography. Conclusion The study results suggest that ultrasonography is useful for the preoperative examination of subcutaneous benign lesions.
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Letter Case Reports
Localized contact urticaria caused by lidocaine/tetracaine peel.
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To describe the acute and late ocular manifestations of toxic epidermal necrosis (TEN), Stevens-Johnson syndrome (SJS), and overlap syndrome and to identify predictors for the development of ocular complications. ⋯ Ocular involvement is common in patients with SJS and TEN. Late complications are more frequent in patients with severe initial eye involvement but may also develop in patients without patent initial ocular symptoms.
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Randomized Controlled Trial Multicenter Study
Topical tretinoin therapy and all-cause mortality.
To evaluate the relation of topical tretinoin, a commonly used retinoid cream, with all-cause mortality in the Veterans Affairs Topical Tretinoin Chemoprevention Trial (VATTC). The planned outcome of this trial was risk of keratinocyte carcinoma, and systemic administration of certain retinoid compounds has been shown to reduce risk of this cancer but has also been associated with increased mortality risk among smokers. ⋯ We observed an association of topical tretinoin therapy with death, but we do not infer a causal association that current evidence suggests is unlikely.