Cutis
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Case Reports
Multiple congenital plaquelike glomuvenous malformations with type 2 segmental involvement.
Multiple congenital glomuvenous malformations (GVMs) are rare. Almost all reported cases describe the multiple congenital plaquelike GVM variant. We report a case of multiple congenital plaquelike GVMs suggestive of type 2 segmental involvement following Blaschko lines.
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We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment. After falling and scraping his left elbow, bacitracin ointment was applied to the wound. Within minutes, he experienced an adverse reaction consisting of bilateral pruritus of the feet, which quickly progressed to his head; diaphoresis; nausea; vomiting; facial pallor; and hives. ⋯ He was taken to the emergency department and given intravenous methylprednisolone sodium succinate and intravenous diphenhydramine hydrochloride. He was kept for observation, recovered well, and was discharged with prescriptions for prednisone and diphenhydramine hydrochloride. We discuss other similar cases so physicians continue to be aware of this rare yet potentially life-threatening reaction to a commonly used medication.
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Review Case Reports
Acute hemorrhagic edema of infancy: case reports and a review of the literature.
Acute hemorrhagic edema of infancy (AHEI) is an unusual form of leukocytoclastic vasculitis that affects children younger than 2 years and frequently is preceded by drug intake, vaccination, or a variety of infections. It is characterized by an abrupt onset of fever, purpuric lesions, and peripheral edema on the face and extremities that may be confused with other dermatoses. The course is benign with spontaneous resolution. We present 2 infants with AHEI and review the clinical manifestations, histology, and differential diagnosis.
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Treating clinically uninfected venous leg ulcers or superficial diabetic foot ulcers with systemic antimicrobial agents does not accelerate healing, even when pathogens grow from cultures of the wounds. Topical antibiotics do not prevent infections following routine dermatologic surgical procedures or minor wounds in an emergency department, but they are effective in reducing infections following minor trauma in children.
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Randomized Controlled Trial
A combined oral contraceptive containing 3-mg drospirenone/ 20-microg ethinyl estradiol in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment.
This study compared the efficacy of a low-dose combined oral contraceptive (COC) containing 3-mg drospirenone and 20-microg ethinyl estradiol (3-mg DRSP/20-microg EE) administered in a 24-day active pill/4-day inert pill (24/4) regimen and placebo in women with moderate acne vulgaris during 6 treatment cycles. A total of 534 participants were randomized and dispensed study medication (n = 266 [3-mg DRSP/20-microg EE 24/4 regimen COC group]; n = 268 [placebo group]). Women of reproductive age were eligible for inclusion in the study. ⋯ The mean nodule count remained essentially constant throughout the study and was low in both treatment groups. There was a significantly higher probability that a participant had an improved assessment on the investigator's overall improvement rating scale (odds ratio [OR], 4.02; 95% CI [confidence interval], 2.29-7.31; P < .0001) and participant's overall self-assessment rating scale (OR, 2.82; 95% CI, 1.60-5.13; P = .0005) in the 3-mg DRSP/20-microg EE 24/4 regimen COC group than in the placebo group. The COC 3-mg DRSP/20-microg EE 24/4 regimen is a suitable option for women with moderate acne vulgaris who require contraception.