Minerva medica
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This study aims to elucidate the role of METTL3 in aggravating the progression of NPC through m6A modification on Snail and thus the stimulated epithelial-mesenchymal transition (EMT). ⋯ METTL3 is upregulated in NPC, which regulates EMT and metastasis in NPC cells through m6A-modified Snail mRNA.
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To date, there are no doubts about the evaluation of patients with syncope, while differential diagnoses between presyncope and nonspecific symptoms, generically referred to as dizziness, are complex and not clearly standardized. This paper aims to highlight the most frequent vestibular diseases, which can mimic a presyncopal episode in adult and older patients. It should be noted that nonspecific symptoms may be caused by multiple conditions, and they can coexist in the same person, making diagnosis even more difficult. Due to nonspecific symptoms and diagnostic complexity, evaluation of patients with presyncope or dizziness should be multidisciplinary, involving the syncope expert and the audiologist, since the first evaluation of the patient in the Emergency Department.