Minerva medica
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Arthrosis is now intended as a multifactorial pathology that involves various joints and is caused by different biological functional alterations at the basis of the joints damage. Considering this new evidence, the prevention and the conservative treatment of arthrosis acquire an important role with respect to a surgical approach. The "Osteo-Experience" project was designed to collect, describe and compare the personal experiences of osteoarticular specialists in the field of the conservative treatment of the various forms of arthrosis. In addition, some useful insights for a correct management of conservative therapy in respect to the various forms of arthrosis were provided. ⋯ Observations collected within the "Osteo-Experience" project show that a more conscious use of the conservative therapy should be pursued for arthrosis. The present study denotes how it is necessary to better define some therapeutic schemes based on the different clinical characteristics of the patient, to improve the clinical outcome.
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The purpose of this study was to explore the mechanism by which microRNA-196b exerts a tumor promotion effect on ovarian cancer (OCa). ⋯ MicroRNA-196b was highly expressed in OCa tissues, which can promote the proliferation, invasiveness and migratory ability of OCa cells by targeting ZMYND11. In addition, the expression disorder of microRNA-196b was associated with the malignant development of OCa.
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related disease (COVID-19) is an infectious disease characterized by systemic inflammation, which might enhance baseline thrombotic risk, especially in hospitalized patients. Little is, however, known about predictors of thrombotic complications in patients with COVID-19. ⋯ Patients with COVID-19 are at increased risk for thrombosis and might be stratified on admission based on lower Pao2/FiO2 ratio, higher D-dimer levels and history of major hemorrhages.