Minerva medica
The most recent articles from:
Minerva Med.
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Endostatin (ES) is an endogenous angiogenesis inhibitor. It is confirmed that ES has antitumor effects and plays a crucial part in regulating vascular smooth cells' proliferation. However, ES's effect on pulmonary hypertension (PH) is unclear. We aimed to determine the effect of ES on PH's pathogenesis. ⋯ The administration of ES may be a new treatment for PH and PA remodeling, associating with the down-regulation of VEGF production.