Tijdschr Diergeneesk
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Tijdschr Diergeneesk · Feb 1989
Review[Medical hemostasis. II. Systemic hemostatics, a critical evaluation].
The control of spontaneous and traumatic haemorrhage is a matter of constant concern to veterinary practitioners. In some instances, the control of bleeding may be relatively simple using some topical therapeutic procedure, but when haemostatic defects are present, treatment with topical agents alone might not be sufficient, and more radical and life-saving procedures are indicated: replacement therapy with blood or blood products. As this is not easy to perform in most veterinary clinical situations, any therapeutic agent, which facilitates control of haemorrhage is a welcome addition to the therapeutic armament. ⋯ Double-blind prospective trials with quantitation of loss of blood showed that antifibrinolytic agents such as tranexamic acid are clinically effective in certain conditions in humans. Because of their mode of action, it might reasonably be expected that these drugs might have positive results in veterinary medicine. Therefore, clinical trials with antifibrinolytic agents are urgently indicated to evaluate the effectiveness and side-effects of these drugs in animals showing severe bleeding or in the prevention of peroperative haemorrhage.
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Clinical studies using a new drug for the treatment of hip dysplasia were done in approximately twenty dogs. Caniplasine was administered rather than combined treatment with phenylbutazone and a corticosteroid. The preliminary results show that this agent has a therapeutic effect. The precise mechanism of action is still obscure.