Tijdschr Diergeneesk
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Narcolepsy is an incurable non-progressive disease of the central nervous system. In humans, narcolepsy causes excessive drowsiness during the day (sometimes a sleep-attack occurs), cataplexy (sudden loss of muscle tone), hallucinations, and sleep paralysis. In the horse and other mammals cataplexy is the most frequently observed symptom. ⋯ Cataplexy (which can be induced by physostigmine injection) confirms the diagnosis. Several drugs are available for the treatment of narcolepsy in humans. However there are a few data on the results of treatment of narcolepsy in the horse.
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Tijdschr Diergeneesk · Jul 1993
[Analgesics; the use of aspirin in dogs; effects of tablet type and food intake on plasma salicylate level].
Administration of acetylsalicylic acid (aspirin) in the dog may cause gastric mucosal damage. Enteric-coated tablets protect the canine stomach during oral aspirin medication. A therapeutic plasma salicylate concentration can be attained using enteric-coated aspirin tablets at a dosage of 25 mg/kg TID. ⋯ It is concluded that, when using enteric-coated tablets, the plasma salicylate concentration in the dog after oral medication is strongly influenced by the aspirin dosage, the tablet type and the feeding pattern. Large enteric-coated tablets may accumulate in the stomach over several days and are not suitable for use in the dog. The gastric accumulation is caused by the enteric-coating of the large tablets and not by the aspirin medication.