Tijdschr Diergeneesk
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Tijdschr Diergeneesk · Jul 1990
Comparative Study[Intramuscularly administered non-opiate anesthesia in dogs. A report on the use of ketamine/xylazine, tiletamine/zolazepam, ketamine/midazolam and metomidine].
In the present paper, findings on the use of ketamine/xylazine, ketamine/midazolam, tiletamine/zolazepam, and medetomidine following intramuscular injection in dogs are reported. The combined use of ketamine/xylazine induced anaesthesia, the duration of which was thirty minutes. Untoward side-effects were not observed. ⋯ Neither the combination ketamine/midazolam nor medetomidine induced a surgical level of anaesthesia. Post-anesthetic muscle spasms were a frequently observed side-effect when the combination ketamine/midazolam was administered. The use of medetomidine resulted in a qualitatively satisfactory and prolonged sedation.
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Tijdschr Diergeneesk · Feb 1989
Review[Medical hemostasis. II. Systemic hemostatics, a critical evaluation].
The control of spontaneous and traumatic haemorrhage is a matter of constant concern to veterinary practitioners. In some instances, the control of bleeding may be relatively simple using some topical therapeutic procedure, but when haemostatic defects are present, treatment with topical agents alone might not be sufficient, and more radical and life-saving procedures are indicated: replacement therapy with blood or blood products. As this is not easy to perform in most veterinary clinical situations, any therapeutic agent, which facilitates control of haemorrhage is a welcome addition to the therapeutic armament. ⋯ Double-blind prospective trials with quantitation of loss of blood showed that antifibrinolytic agents such as tranexamic acid are clinically effective in certain conditions in humans. Because of their mode of action, it might reasonably be expected that these drugs might have positive results in veterinary medicine. Therefore, clinical trials with antifibrinolytic agents are urgently indicated to evaluate the effectiveness and side-effects of these drugs in animals showing severe bleeding or in the prevention of peroperative haemorrhage.